High Purity Tacrolimus CAS 104987-11-3 Tacrolimus Powder Tacrolimus

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: EP
• Certification: Ep
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Transport Package: Fiber Drum
• Specification: 25KG
• Origin: China
• Production Capacity: 500mt/Year

Product Description

Product Description

Product Name:	Tacrolimus
CAS:	104987-11-3
MF:	C44H69NO12
MW:	804.02
EINECS:	1308068-626-2
Melting point	113-115°C
Boiling point	871.7±75.0 °C(Predicted)
density	1.19±0.1 g/cm3(Predicted)
Fp	2ºC
storage temp.	Sealed in dry, Store in freezer, under -20°C
solubility	DMSO: >3 mg/mL
form	solid
pka	9.97±0.70(Predicted)
color	white

Tacrolimus, also known as FK506, is a fermentation product isolated from Streptomyces. It is a macrolide antibiotic and a powerful new immunosuppressant, mainly by inhibiting interleukin-2 The release of (IL-2) completely inhibits the effect of T lymphocytes, which is 100 times stronger than cyclosporine (CsA). In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.

Function
1.Tacrolimus is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
2.Tacrolimus is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.

Applications
1.The mechanism of action of tacrolimus in atopic dermatitis is not known.  the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.
 

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Packaging & Shipping

Our Advantages

1. Best price of this product due to our strictly control over raw materials and production costs.
2. Our company is confident at the product quality. Professional R&D technology team and equipment which keep products quality better and better.
3. Factory locates in national new material industrial park where guarantees safe and continuous production.
4. More than 15 years chemical production and exporting experience, and good relationship with customs and ship agents, which guarantee fast and safe export.
5. Timely after service resolves your worry for international trade.

FAQ

Q: What is your payment terms?
A: We accept all payment terms including TT, LC, DP, CAD.

Q: What is your delivery time?
A: Usually we will arrange the delivery within 5 -15 days.

Q: What is your packing? 
A: It depends on the products, we normally use standard package from our factory.
We can also arrange customized packages according to customers' requirements.

Q: What is the validity of the products? 
A: We guarantee that the cargoes have Min. 80% shelf life on the delivery date.

Q: How about your after-sale service?
A: We have profession team for loading, as well as the logistics team for documents. Our logistics team will send arrival notice for customers and keeping eyes for their feedback once received our cargoes. If any issue, we will solve it at once and our customers are always long-term partners.
 
Q: How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.