Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name: | Indometacin |
Synonyms: | 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid;indomethacin crystalline;indomethacin methanol solution;indomethacin usp;AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE |
CAS: | 53-86-1 |
MF: | C19H16ClNO4 |
MW: | 357.79 |
EINECS: | 200-186-5 |
Melting point | 158-162 °C |
Boiling point | 499.4±45.0 °C(Predicted) |
density | 1.2135 (rough estimate) |
Indomethacin is a kind of stronger corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reducing the synthesis of prostaglandin (PG), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., and produce antipyretic, analgesic and anti-inflammatory effects.Indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect is better than bute, 84 times better than hydrocortis, and sugar cortical hormone, used in combination with aspirin, bute, can reduce their dosage, toxic and side effects, improve curative effect; Second is antipyretic effect, 10 times than amidopyrine ;its analgesic action is weak , only to the inflammatory pain has obvious analgesic effect, but the effect is good for inflammatory pain than Baotai loose, analgin and salicylic acid.
Mainly used on the efficacy of drugs difficult to tolerate, or not significant rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on. Can also be used for acute gout and cancer, fever, or other difficult to control fever.